Detection of DKK-1,CYFRA21-1,NSE and CEA in patients with esophageal cancer
Pages: 2415-2417
Year: 2017 Issue: 15
Journal: Journal of Modern Oncology
Abstract: Objective:To investigate the clinical values of secreted protein Dikkopf1(DKK-1),carcino-embryonic antigen(CEA),cytokeratin 19 fragment antigen 21-1(CYFRA21-1) and neuron-specific enolization enzyme(NSE) for diagnosis in early stage of esophageal cancer.Methods:Totally 41 patients with stage Ⅰ-Ⅱ esophageal cancer and 32 healthy volunteers were selected.CYFRA21-1,NSE and CEA were detected by electrochemical luminescence immunity analyzer and DKK-1 was detected by improved double antibody sandwich enzyme-linked immunosorbent method.Results:The contents of serum DKK-1,CYFRA21-1,NSE and CEA in the early esophageal cancer patients were significantly higher than that of the control group(P<0.05).Also contents of the factors were positively correlated with tumor stage.Combined the results of four indicators can make diagnostic sensitivity in 90.2% and specificity in 95.1% for esophageal cancer.Conclusion:Joint detection of serum DKK 1,NSE,CEA and CYFRA21-1 can improve the diagnostic sensitivity and specificity for patients with esophageal cancer,particularly benefit to those with stage Ⅰ-Ⅱ.
Year: 2017 Issue: 15
Journal: Journal of Modern Oncology
Abstract: Objective:To investigate the clinical values of secreted protein Dikkopf1(DKK-1),carcino-embryonic antigen(CEA),cytokeratin 19 fragment antigen 21-1(CYFRA21-1) and neuron-specific enolization enzyme(NSE) for diagnosis in early stage of esophageal cancer.Methods:Totally 41 patients with stage Ⅰ-Ⅱ esophageal cancer and 32 healthy volunteers were selected.CYFRA21-1,NSE and CEA were detected by electrochemical luminescence immunity analyzer and DKK-1 was detected by improved double antibody sandwich enzyme-linked immunosorbent method.Results:The contents of serum DKK-1,CYFRA21-1,NSE and CEA in the early esophageal cancer patients were significantly higher than that of the control group(P<0.05).Also contents of the factors were positively correlated with tumor stage.Combined the results of four indicators can make diagnostic sensitivity in 90.2% and specificity in 95.1% for esophageal cancer.Conclusion:Joint detection of serum DKK 1,NSE,CEA and CYFRA21-1 can improve the diagnostic sensitivity and specificity for patients with esophageal cancer,particularly benefit to those with stage Ⅰ-Ⅱ.
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