Activation of Parvalbumin-Positive Neurons in Both Retina and Primary Visual Cortex Improves the Feature-Selectivity of Primary Visual Cortex Neurons
Author(s): Jinggang Duan, Hang Fu, Jiayi Zhang, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Brain Science, Fudan University
Pages: 255-263
Year: 2017 Issue: 3
Journal: Neuroscience Bulletin
Keyword: Parvalbumin neurons; Primary visual cortex; Retinal ganglion cells; Optogenetics;
Abstract: Several recent studies using either viral or transgenic mouse models have shown different results on whether the activation of parvalbumin-positive(PV~+)neurons expressing channelrhodopsin-2(ChR2) in the primary visual cortex(V1) improves the orientation-and direction-selectivity of V1 neurons. Although this discrepancy was thoroughly discussed in a follow-up communication, the issue of using different models to express ChR2 in V1 was not mentioned. We found that ChR2 was expressed in retinal ganglion cells(RGCs) and V1 neurons in ChR2fl/~+; PV-Cre mice. Our results showed that the activation of PV~+RGCs using white drifting gratings alone significantly decreased the firing rates of V1 neurons and improved their direction-and orientation-selectivity. Longduration activation of PV~+interneurons in V1 further enhanced the feature-selectivity of V1 neurons in anesthetized mice, confirming the conclusions from previous findings. These results suggest that the activation of both PV~+RGCs and V1 neurons improves feature-selectivity in mice.
Pages: 255-263
Year: 2017 Issue: 3
Journal: Neuroscience Bulletin
Keyword: Parvalbumin neurons; Primary visual cortex; Retinal ganglion cells; Optogenetics;
Abstract: Several recent studies using either viral or transgenic mouse models have shown different results on whether the activation of parvalbumin-positive(PV~+)neurons expressing channelrhodopsin-2(ChR2) in the primary visual cortex(V1) improves the orientation-and direction-selectivity of V1 neurons. Although this discrepancy was thoroughly discussed in a follow-up communication, the issue of using different models to express ChR2 in V1 was not mentioned. We found that ChR2 was expressed in retinal ganglion cells(RGCs) and V1 neurons in ChR2fl/~+; PV-Cre mice. Our results showed that the activation of PV~+RGCs using white drifting gratings alone significantly decreased the firing rates of V1 neurons and improved their direction-and orientation-selectivity. Longduration activation of PV~+interneurons in V1 further enhanced the feature-selectivity of V1 neurons in anesthetized mice, confirming the conclusions from previous findings. These results suggest that the activation of both PV~+RGCs and V1 neurons improves feature-selectivity in mice.
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