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Structured abstracts of sentinel articles: Picket
Introduction of allergenic foods from 3 months of age reduces incidence of food allergy in breastfed infants
  1. Rebecca A Dalrymple,
  2. Niten Makwana
  1. Department of Paediatrics, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
  1. Correspondence to Dr Rebecca A Dalrymple, Department of Paediatrics, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK; rebecca.dicks{at}doctors.org.uk

https://doi.org/10.1136/archdischild-2016-311809

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    Study question

    Patients: 1303 exclusively breastfed, well, singleton infants, aged 13–17 weeks recruited from the general population in England and Wales.

    Early introduction group: Introduction of six allergenic foods: cow’s milk, peanut, hen’s egg, sesame, whitefish and wheat. Minimum amounts defined as 3 g once a week of at least five of the foods for 5 weeks between 3 and 6 months of age.

    Standard introduction group: Continue to breast feed until 6 months of age, compliance defined as no consumption of allergenic foods including less than 300 mL of formula per day.

    Outcomes: Challenge-proven food allergy to one or more of the six early introduction foods at age 1–3 years.

    Analysis: Intention-to-treat (ITT) analysis and per-protocol analysis (PPA). In PPA, infants who were not compliant with their diet using the above definitions were excluded …

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    Footnotes

    • Contributors RAD wrote the abstract and NM wrote the commentary.

    • Provenance and peer review Not commissioned; internally peer reviewed.