Observation of the Effect of Preoperative Neoadjuvant Chemotherapy on Histopathological Dynamic Changes and the Short-term and Long-term Efficacy of Cervical Cancer
Pages: 920-923
Year: 2017 Issue: 6
Journal: Practical Journal of Cancer
Abstract: Objective To explore the effect of preoperative neoadjuvant chemotherapy(NACT) on histopathological dynamic changes and the short-term and long-term efficacy of cervical cancer.Methods 67 patients with stage Ⅰ b-Ⅱ a2 cervical squamous cell carcinoma who received elective operation were selected as the study subjects,and all were confirmed by clinical pathology.The subjects were divided into the control group(32 cases) and NACT group (35 cases) according to therapeutic methods.The control group was treated by operation directly,while NACT group was treated by platinum-based NACT and 2 to 3 weeks after the end of chemotherapy,treated by operation.Efficacy of the 2 groups was evaluated.Histopathological Ⅱ + Ⅲ grade were effective group,and 0 + Ⅰ grade was ineffective group;The levels of squamous cell carcinoma related antigen (SCC-Ag) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) level in NACT effective group,ineffective group and the control group were tested.The lymph node metastasis rate,parametrial infiltration rate and histopathological changes were recorded;All patients were followed up to May 2015,and the recurrence rate and mortality rate were recorded.Results Effective rate of NACT imaging was 71.43％ (25/35) while of pathologic histology was 60.00％ (21/35).After NACT,tumor cell necrosis and deformation,vascular tissue and fibrous tissue increase replaced tumor tissue.SCC-Ag and CYFRA21-1 in NACT effective group were decreased after chemotherapy,and they were lower than those in ineffective group and the control group after NACT(P ＜ 0.05);There was no significant difference in above indexes between the ineffective group and the control group before and after the chemotherapy.Cervical deep muscularis infiltration rate,postoperative recurrence rate and 1-year survival rate showed no significant differences between NACT group and the control group.The positive rate of pelvic lymph node in NACT group(11.43％) was lower than that the control group (37.50％) (P ＜ 0.05);The postoperative recurrence rate in NACT effective group (0％) was lower than that in ineffective group(21.42％) (P ＜ 0.05).Conclusion Preoperative NACT can reduce the levels of tumor markers of cervical cancer,and promote changes of pathologic histology,providing objective information for clinical evaluation.
Year: 2017 Issue: 6
Journal: Practical Journal of Cancer
Abstract: Objective To explore the effect of preoperative neoadjuvant chemotherapy(NACT) on histopathological dynamic changes and the short-term and long-term efficacy of cervical cancer.Methods 67 patients with stage Ⅰ b-Ⅱ a2 cervical squamous cell carcinoma who received elective operation were selected as the study subjects,and all were confirmed by clinical pathology.The subjects were divided into the control group(32 cases) and NACT group (35 cases) according to therapeutic methods.The control group was treated by operation directly,while NACT group was treated by platinum-based NACT and 2 to 3 weeks after the end of chemotherapy,treated by operation.Efficacy of the 2 groups was evaluated.Histopathological Ⅱ + Ⅲ grade were effective group,and 0 + Ⅰ grade was ineffective group;The levels of squamous cell carcinoma related antigen (SCC-Ag) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) level in NACT effective group,ineffective group and the control group were tested.The lymph node metastasis rate,parametrial infiltration rate and histopathological changes were recorded;All patients were followed up to May 2015,and the recurrence rate and mortality rate were recorded.Results Effective rate of NACT imaging was 71.43％ (25/35) while of pathologic histology was 60.00％ (21/35).After NACT,tumor cell necrosis and deformation,vascular tissue and fibrous tissue increase replaced tumor tissue.SCC-Ag and CYFRA21-1 in NACT effective group were decreased after chemotherapy,and they were lower than those in ineffective group and the control group after NACT(P ＜ 0.05);There was no significant difference in above indexes between the ineffective group and the control group before and after the chemotherapy.Cervical deep muscularis infiltration rate,postoperative recurrence rate and 1-year survival rate showed no significant differences between NACT group and the control group.The positive rate of pelvic lymph node in NACT group(11.43％) was lower than that the control group (37.50％) (P ＜ 0.05);The postoperative recurrence rate in NACT effective group (0％) was lower than that in ineffective group(21.42％) (P ＜ 0.05).Conclusion Preoperative NACT can reduce the levels of tumor markers of cervical cancer,and promote changes of pathologic histology,providing objective information for clinical evaluation.
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