Clinical study of oral dydrogesterone in early pregnancy in regulating cytokine production and prevention of recurrent abortion
Pages: 122-126
Year: 2017 Issue: 6
Journal: The Chinese Journal of Human Sexuality
Abstract: Objectives:To study the effect of oral dydrogesterone in early pregnancy on pregnancy outcome and its correlation with Th1 and Th2 cytokine levels.Methods:366 patients with recurrent abortion were included and randomly divided into experimental group and control group Another 168 healthy female without abortion history were also included.The pregnancy outcomes were statistically analyzed.The Th1 (IFN-γ and IFN-oα) and Th2 (IL-4 and IL-10) cytokines levels in serum were also detected at recruitment (4 8 weeks of gestation) and at abortion or 20 weeks of gestation.Results:The occurrence of abortions in experimental group was significantly high-er than that in the control groups (7.2％ vs 17.7％,P =0.024).The mean gestational age at delivery increased significantly in the experimental group compared with that in the control group (38.1 ± 2.8 vs 37.1 ± 2.4,P ＜ 0.001).The percentage change in the serum level of IFN-y was found to be significantly higher in the experimental group and control groups compared with that in the healthy pregnant controls (P ＜ 0.05).The serum cytokine levels for adverse pregnancy outcomes such as preterm delivery,low-birth weight babies and small-for-date babies showed a statistically significant difference only at the time of recruitment (4-8 weeks).Conclusion:The use of dydrogesterone in women with recurrent abortions can improve the pregnancy outcome,such as a reduction in abortions and improved gestational age and baby weight at delivery.But these outcomes are not modulated by Thl and Th2 cytokine production.
Year: 2017 Issue: 6
Journal: The Chinese Journal of Human Sexuality
Abstract: Objectives:To study the effect of oral dydrogesterone in early pregnancy on pregnancy outcome and its correlation with Th1 and Th2 cytokine levels.Methods:366 patients with recurrent abortion were included and randomly divided into experimental group and control group Another 168 healthy female without abortion history were also included.The pregnancy outcomes were statistically analyzed.The Th1 (IFN-γ and IFN-oα) and Th2 (IL-4 and IL-10) cytokines levels in serum were also detected at recruitment (4 8 weeks of gestation) and at abortion or 20 weeks of gestation.Results:The occurrence of abortions in experimental group was significantly high-er than that in the control groups (7.2％ vs 17.7％,P =0.024).The mean gestational age at delivery increased significantly in the experimental group compared with that in the control group (38.1 ± 2.8 vs 37.1 ± 2.4,P ＜ 0.001).The percentage change in the serum level of IFN-y was found to be significantly higher in the experimental group and control groups compared with that in the healthy pregnant controls (P ＜ 0.05).The serum cytokine levels for adverse pregnancy outcomes such as preterm delivery,low-birth weight babies and small-for-date babies showed a statistically significant difference only at the time of recruitment (4-8 weeks).Conclusion:The use of dydrogesterone in women with recurrent abortions can improve the pregnancy outcome,such as a reduction in abortions and improved gestational age and baby weight at delivery.But these outcomes are not modulated by Thl and Th2 cytokine production.
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