Effectiveness of lymphocyte immunotherapy for patients with unexplained infertility before in vitro fertilization-embryo transfer
Pages: 146-149
Year: 2017 Issue: 6
Journal: The Chinese Journal of Human Sexuality
Abstract: Objectives:To investigate the effect of lymphocyte immunotherapy on patients with unexplained infertility undergoing in vitro fertilization-embryo transfer (IVF-ET).Methods:462 patients diagnosed as unexplained infertility undergoing IVF caused by lacking blocking antibodies (BA) from May 2011 to September 2015 were selected and randomly divided into two groups,treatment group (n =187) and control group (n =275).The percentages of anti-CD-3 +,CD4 + and CD8 + were examined by flow cytometry,and lymphocytes immunotherapy was performed in the treatment group.Pregnancy outcome was compared between the two groups.Results:The expression rate of anti-CD3 +,CD4 + and CD8 + in the peripheral blood in active immunotherapy were statistically higher than that in the control group (P ＜ 0.05).The pregnancy rate and implantation rate in the treatment group was higher (P ＜ 0.05).There was no significant difference in the miscarriage rate,the number of retrieved oocytes,fertilization rate,cleavagerate,embryo grading and the number of embryos transplanted between the two groups (P ＞ 0.05).Conclusion:Lymphocyte immunotherapy can improve the outcome of IVF-ET in the patient with unexplained infertility,an effective method of treating unexplained infertility.
Year: 2017 Issue: 6
Journal: The Chinese Journal of Human Sexuality
Abstract: Objectives:To investigate the effect of lymphocyte immunotherapy on patients with unexplained infertility undergoing in vitro fertilization-embryo transfer (IVF-ET).Methods:462 patients diagnosed as unexplained infertility undergoing IVF caused by lacking blocking antibodies (BA) from May 2011 to September 2015 were selected and randomly divided into two groups,treatment group (n =187) and control group (n =275).The percentages of anti-CD-3 +,CD4 + and CD8 + were examined by flow cytometry,and lymphocytes immunotherapy was performed in the treatment group.Pregnancy outcome was compared between the two groups.Results:The expression rate of anti-CD3 +,CD4 + and CD8 + in the peripheral blood in active immunotherapy were statistically higher than that in the control group (P ＜ 0.05).The pregnancy rate and implantation rate in the treatment group was higher (P ＜ 0.05).There was no significant difference in the miscarriage rate,the number of retrieved oocytes,fertilization rate,cleavagerate,embryo grading and the number of embryos transplanted between the two groups (P ＞ 0.05).Conclusion:Lymphocyte immunotherapy can improve the outcome of IVF-ET in the patient with unexplained infertility,an effective method of treating unexplained infertility.
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