Author(s): Wang Bing, Wang Jiangqiao
Pages: 73-75
Year: 2017 Issue:  14
Journal: Chinese Journal of Practical Nervous Diseases
Keyword:  Alzheimer's disease; Atorvastatin; Heme oxygenase;
Abstract: Objective To observe the effect of atorvastatin on heme oxygenase in both parietal cortex and cerebellum in model rats with Alzheimer''s disease induced by beta-amyloid protein (1-42).Methods Forty Wistar rats were randomly divided into normal control group,statin control group,model control group and statin treatment group,ten rats in each group.Then the expressions of HO-1 and HO-2 in both parietal cortex and cerebellum were detected by Western blot method.Results In parietal cortex area,the HO-1 expression in the statin treatment group increased and showed statistically significant difference compared with that in the other three groups,however,there was no significant difference in terms of HO-2 expression among the four groups.In cerebellum area,the statin treatment group showed the increased HO-2 expression and presented significant difference in comparison to others,but no significant difference was found on HO-1 expression among the four groups.Conclusion Atorvastatin can up-regulate the expressions of both HO-1 and HO-2 in different parts of the brain and can alleviate the damage of central nervous system.