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Exercise stress test scoring was more accurate in risk stratification when the algorithm it used included gender as a factor, according to a two-cohort study with nearly equal representation of men and women reported in JAMA Cardiology.
"For years we've used Duke Treadmill Score for both men and women, but as most physicians know, Duke Treadmill Score was developed in men a long time ago, validated in men, and not really well validated in women," senior author Leslie Cho of the Cleveland Clinic, explains in this exclusive MedPage Today video.
Her group developed and validated a new score that treated women and men separately, showing "reasonable" discrimination and calibration for 10-year all-cause mortality and better net reclassification compared with the Duke Treadmill Score or Lauer nomogram.
Disclosures
The study was supported by the Women's Cardiovascular Center, Cleveland Clinic, and Karo's Chair for Women's Cardiovascular Research.
The researchers disclosed no relevant relationships with industry.
Primary Source
JAMA Cardiology
Source Reference: Cremer PC, et al "Use of sex-specific clinical and exercise risk scores to identify patients at increased risk for all-cause mortality" JAMA Cardiol 2016; DOI: 10.1001/jamacardio.2016.3720.