Study on Protective Effects of Li Medicine Chushi Qufeng Decoction on Arthritis Model Rats Induced by Chicken Type Ⅱ Collagen
Author(s): ZHANG Li, ZHANG Yiyun, FU Hong, WANG Kaiyu, LEI Lingfang, WANG Chuntao, Dept. of Pharmacy, Hainan Provincial Hospital of TCM, Pharmaceutical Institute of Hainan Province
Pages: 3088-3090
Year: 2016 Issue: 22
Journal: China Pharmacy
Keyword: Li medicine; Chushi qufeng decoction; Rheumatoid arthritis; TNF-α; IL-1β; Rat;
Abstract: OBJECTIVE:To study the protective effects of Li medicine Chushi qufeng decoction on arthritis model rats. METHODS:60 rats were randomly divided into normal group,model group,positive group and Chushi qufeng decoction high-dose,medium-dose and low-dose groups [45.9,22.95,11.48 g(crude drug)/kg]. Except for normal group,those groups were given chicken type Ⅱ collagen to induce arthritis model. After modeling,normal group and model group were given normal saline intragastrically,once a day,for consecutive 12 d;Chushi qufeng decoction groups were given relevant medicine intragastrically;positive group was given leflunomide 4.5 mg/kg on 1st-3rd day and 1.8 mg/kg on 4th-12 th day. The degree of joint lesion in rats were scored. The degree of joint swelling was determined as well as the serum levels of TNF-α,IL-1 β and type Ⅱ collagen antibody. RESULTS:Compared with normal group,arthritis index,degree of joint swelling,the serum levels of TNF-α,IL-1β and type Ⅱ collagen antibody increased significantly in model group(P<0.01). Compared with model group,pathological score of positive group and Chushi qufeng decoction high-dose group decreased significantly,and serum levels of TNF-α,IL-1β and type Ⅱ collagen antibody decreased significantly in treatment groups(P<0.05 or P<0.01). CONCLUSIONS:Li medicine Chushi qufeng decoction has certain protective effect on arthritis model rats induced by chicken type Ⅱ collagen.
Pages: 3088-3090
Year: 2016 Issue: 22
Journal: China Pharmacy
Keyword: Li medicine; Chushi qufeng decoction; Rheumatoid arthritis; TNF-α; IL-1β; Rat;
Abstract: OBJECTIVE:To study the protective effects of Li medicine Chushi qufeng decoction on arthritis model rats. METHODS:60 rats were randomly divided into normal group,model group,positive group and Chushi qufeng decoction high-dose,medium-dose and low-dose groups [45.9,22.95,11.48 g(crude drug)/kg]. Except for normal group,those groups were given chicken type Ⅱ collagen to induce arthritis model. After modeling,normal group and model group were given normal saline intragastrically,once a day,for consecutive 12 d;Chushi qufeng decoction groups were given relevant medicine intragastrically;positive group was given leflunomide 4.5 mg/kg on 1st-3rd day and 1.8 mg/kg on 4th-12 th day. The degree of joint lesion in rats were scored. The degree of joint swelling was determined as well as the serum levels of TNF-α,IL-1 β and type Ⅱ collagen antibody. RESULTS:Compared with normal group,arthritis index,degree of joint swelling,the serum levels of TNF-α,IL-1β and type Ⅱ collagen antibody increased significantly in model group(P<0.01). Compared with model group,pathological score of positive group and Chushi qufeng decoction high-dose group decreased significantly,and serum levels of TNF-α,IL-1β and type Ⅱ collagen antibody decreased significantly in treatment groups(P<0.05 or P<0.01). CONCLUSIONS:Li medicine Chushi qufeng decoction has certain protective effect on arthritis model rats induced by chicken type Ⅱ collagen.
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