Study on the Extraction Technology of Compound Qima Capsules
Author(s): WANG Luolin, WU Xiaobin, ZHOU Rong, ZHANG Jianjun, YUAN Liuping, Guangdong Province Engineering and Technology Research Institute of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Research and Development, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Livzon Group Limin Pharmaceutical Factory
Pages: 3128-3131
Year: 2016 Issue: 22
Journal: China Pharmacy
Keyword: Compound qima capsules; Antihypertensive effect; Extraction technology; Astragaloside; Isoflavone grape glycosides; Orthogonal test;
Abstract: OBJECTIVE:To optimize the extraction technology of Compound qima capsules. METHODS:With the blood pressure lowering of rats as index,pharmacological efficacy test was used to screen the preparation technology(A was whole herb decoction;B was Gastrodia elata fine powder mixed with other decocted medical materials). The extraction technology was optimized by single factor and orthogonal test using the contents of astragaloside and isoflavone grape glycosides and the quality of solid as indexes,with added water,decoction time,decoction times as factors;and the verification test was carried out. RESULTS:Pharmacological efficacy test showed that antihypertensive effect of sample by technology B was superior. The optimal extraction condition of other medical materials of technology B was as follows as 12-fold water per time,decocting for 1.5 h,for 3 times. In verification test,average extraction rates of astragaloside and isoflavone grape glycosides were 64.02% and 51.97%,and average value of the quality of solid was 5.69 g(RSD≤1.92%,n=3). CONCLUSIONS:The optimized extraction technology is stable and feasible.
Pages: 3128-3131
Year: 2016 Issue: 22
Journal: China Pharmacy
Keyword: Compound qima capsules; Antihypertensive effect; Extraction technology; Astragaloside; Isoflavone grape glycosides; Orthogonal test;
Abstract: OBJECTIVE:To optimize the extraction technology of Compound qima capsules. METHODS:With the blood pressure lowering of rats as index,pharmacological efficacy test was used to screen the preparation technology(A was whole herb decoction;B was Gastrodia elata fine powder mixed with other decocted medical materials). The extraction technology was optimized by single factor and orthogonal test using the contents of astragaloside and isoflavone grape glycosides and the quality of solid as indexes,with added water,decoction time,decoction times as factors;and the verification test was carried out. RESULTS:Pharmacological efficacy test showed that antihypertensive effect of sample by technology B was superior. The optimal extraction condition of other medical materials of technology B was as follows as 12-fold water per time,decocting for 1.5 h,for 3 times. In verification test,average extraction rates of astragaloside and isoflavone grape glycosides were 64.02% and 51.97%,and average value of the quality of solid was 5.69 g(RSD≤1.92%,n=3). CONCLUSIONS:The optimized extraction technology is stable and feasible.
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