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Systematic Evaluation and Meta-analysis of Efficacy and Safety of Xifeng Dingchan Pills for Treatment of Parkinson’s Disease
Author(s): LU Jingmin, ZUO Jinhong, LIU Shaonan, YANG Lihong, HE Yihan, CHEN Jing, GUO Xinfeng, Guangdong Provincial Hospital of Traditional Chinese Medicine
Pages: 558-
564
Year: 2016
Issue:
4
Journal: Traditional Chinese Drug Research & Clinical Pharmacology
Keyword: Xifeng Dingchan pills; Parkinson’s disease; Systematic evaluation; Meta-analysis;
Abstract: Objective To systematically evaluate the efficacy and safety of Xifeng Dingchan pills(XDP) in treating Parkinson’s disease(PD).Methods Randomized controlled trials(RCTs)for XDP in treating PD were collected from Chinese and English databases. Cochrane Handbook 5.1 software was used to access the quality of included trials,and Rev Man 5.3 was used to conduct Meta-analysis. Funnel plot and Egger’s test was used to analyze the publication bias.Results A total of 16 studies were included. According to the intervention method,the included RCTs were classified into XDP combined with western medicine(combined intervention) RCTs and XDP alone RCTs. The results of Meta-analysis showed that XDP combined with western medicine(Levodopa and Benserazide Hydrochloride tablets,Piribedil tablets) had better effect on improving Unified Parkinson’s Disease Rating Scale(UPDRS)scores(WMD=-5.67,95 % CI [-7.84,-3.51]),PD symptom scale(Webster)scores(WMD=-2.7,95 % CI[-4.24,-1.16]),and effective rate(RR=1.34,95 % CI[1.23,1.47]) than western medicine. XDP alone showed no statistical significant differences in improving UPDRS score(WMD=-1.24,95%CI[-4.2,1.72]) and effective rate(RR=0.99,95 % CI[0.86,1.15])when compared with western medicine. The GRADE profile showed that the included RCTs were in low quality of evidence. Conclusion XDP combined with Madopar, Madopar+Benserazide Hydrochloride tablets, or Madopar +Piribedil tablets are more effective and safe than western medicine alone,showing no publication bias. The effect of XDP alone is similar to that of the anti-PD drugs. However,for the low quality of methodology, small size of included studies and lower evidence grade,clinicians should be cautious to use the evidence.
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