OAKLAND, Calif. -- Peyton Manning had a little fun with the Oakland Raiders for most of the first half.

And then he got down to business.

Manning, who has been a Raiders killer since becoming the quarterback of the Denver Broncos in 2012, was actually struggling early as he was intercepted twice, leading to 10 points for Oakland.

Then, Manning started to do what he does against the Raiders: dominate. He threw touchdowns on five straight drives as the Broncos turned an early-second quarter scare into a 31-point lead. By the time the fourth quarter started, Manning was smiling on the sideline and backup Brock Osweiler was getting some rare work.

In the end, it was a 41-17 Denver, continuing the Raiders’ misery. Oakland is now 0-9 and has lost 15 straight games dating back to last November.

Making the situation worse? This game wasn't competitive. The Raiders have been proud of keeping games fairly close since Tony Sparano took over as the interim head coach. Dennis Allen was fired after four games. This, though, was Oakland’s worst performance of the season, equaling its 38-14 loss to Miami in London, which was the final straw for Allen.

Offensively, the Raiders could only muster short passes and 30 rushing yards. They went three-and-out nine times. Defensively, Oakland just wilted under the pressure of trying to stop Manning & Co.

The game turned on a play Manning had little to do with. With Oakland leading 10-6, the Broncos looked like they were going to go three-and-out with a third-and-8 situation. However, unheralded second-year running back C.J. Anderson took a short pass from Manning and bolted across the field 51 yards for the go-ahead touchdown. Several Oakland defenders missed Anderson. It gave Denver a 13-10 lead with 2:44 to go in the first half.

"I’m part of the play that really turned the game around” said safety Charles Woodson, who missed a tackle on Anderson. “That’s one I’ll be thinking about all night."

The play started a scoring avalanche. Manning hit Emmanuel Sanders for a 32-yard touchdown pass with 28 seconds to go in the half to give Denver a 10-point lead.

Manning then threw touchdown passes of 10, 32 and 15 yards in the first 13:59 of the second half. He completed 13 of 15 passes on the five touchdown drives.

“He’s Peyton Manning, arguably the best quarterback of all time,” Oakland linebacker Miles Burris said. “You have to mind your P's and Q's.”

The Raiders have seen this movie, though. In Manning’s five games against the Raiders since he joined the Broncos, Denver has outscored the Raiders 175-71. He has thrown 16 touchdowns against the Raiders in that span.

“Obviously, Peyton is who he is for a reason,” said Oakland defensive end Justin Tuck, who had an interception off Manning to set up the go-ahead touchdown in the second quarter. “He does a great job of adjusting in the game and seeing things that they’re doing well and we’re not and getting his team in position to be successful. We have to figure out ways to do that. We knew going in that we need to play a pretty mistake-free game. Obviously that’s not possible, but closest to that as possible. I thought we did the first 25 minutes.”

The Raiders will get another crack at Manning in Week 17. They just hope it isn’t with a 0-15 record.