Author(s): Ying Qin, Qiu Yuebo, Quzhou People’s Hospital of Zhejiang Province
Pages: 20-22
Year: 2016 Issue:  5
Journal: Journal of Pediatric Pharmacy
Keyword:  bronchiolitis; montelukast; Th17; Treg;
Abstract: Objective: To observe the effect and regulation of montelukast on Th17/Treg in children with bronchiolitis. Methods: A total of 124 children with bronchiolitis were enrolled in this study. Children were randomly divided into control group( n = 62) and observation group( n = 62). The control group was treated with only conventional therapy,while the observation group was treated with montelukast on the basic of control group. The Th17 and Treg were detected by flow cytometer. The expressions of IL-17 and IL-10 were detected by ELISA. The clinical effects of the two groups were compared. Results: Before treatment,Th17,Treg,IL-17,and IL-10 had no significant difference between the two groups( P>0.05). After treatment,the levels of Th17 cells and IL-17 were decreased and the levels of Treg and IL-10 were increased in two groups( P<0.05). However,the improvement was better in observation group than that in control group( P< 0. 05). The disappearance time of symptom and hospital duration was significantly longer than those of observation group( P<0.05). The clinical effective rate was 72.58% in control group,which was significantly lower than that 90.32% of observation group( P<0.05).Conclusion: Montelukast could regulate Th17 / Treg balance in children with bronchiolitis,and is worthy of clinical application.