Doling out too many antibiotics 'will make even scratches deadly': WHO warns that crisis could be worse than Aids

  • Spread of deadly superbugs that evade antibiotics is happening globally
  • It's now a major threat to public health, the World Health Organisation says
  • It could mean minor injuries and common infections become fatal

Deaths from cuts and grazes, diarrhoea and flu will soon be common as antibiotics lose their power to fight minor infections, experts have warned.

The World Health Organisation says the problem has been caused by antibiotics being so widely prescribed that bacteria have begun to evolve and develop resistance.

It claims the crisis is worse than the Aids epidemic – which has caused 25million deaths worldwide – and threatens to turn the clock back on modern medicine.

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Antibiotic resistance needs to be taken as seriously as AIDS was in the 1980s, experts say

Antibiotic resistance needs to be taken as seriously as AIDS was in the 1980s, experts say

The WHO warns that the public should ‘anticipate many more deaths’ as it may become routine for children to develop lethal infections from minor grazes, while hospital operations become deadly as patients are at risk of developing infections that were previously treatable.

Doctors are increasingly finding that antibiotics no longer work against urinary and skin infections, tuberculosis and gonorrhoea.

The WHO is urging the public to take simple precautions, such as washing hands to prevent bacteria from spreading in the first place.

Doctors are also being told to prescribe antibiotics sparingly and ensure patients finish the full course, as if they stop mid-way the bacteria may become resistant. In England last year some 41.7million prescriptions were written out, up from 37.2million in 2006.

SUPERBUGS: THE GUIDE TO BUGS RENDERING ANTIBIOTICS OBSOLETE

MRSA - Patients infected with MRSA (methicillin-resistant Staphylococcus aureus) are 64 per cent more likely to die than those with a non-resistant form of S. aureus.
People infected by resistant superbugs are also likely to stay longer in hospital and may need intensive care, pushing up costs.

C. difficile - This bacteria produces spores that are resistant to high temperatures and are very difficult to eliminate. It is spread through contaminated food and objects and can cause blood poisoning and tears in the large intestine.

E. coli - this now accounts for one in three cases of bacterial infections in the blood in the UK and a new strain is resistant to most antibiotics. It is highly contagious and could cause more than 3,000 deaths a year.

Acinetobacter Baumannii - a common bacteria which is resistant to most antibiotics and which can easily infect patients in a hospital. It can cause meningitis and is fatal in about 80 per cent of patients.

CRKP - this is a bacterium that is associated with extremely difficult to treat blood infections and meningitis. It is resistant to nearly all antibiotics and is fatal in 50 per cent of cases.

Multi-drug resistant tuberculosis is estimated to kill 150,000 people globally each year.

NDM-1 - a bacteria detected in India of which some strains are resistant to all antibiotics.

Dr Keiji Fukuda, the WHO’s assistant director for health security, said: ‘Without urgent, co-ordinated action, the world is headed for a post-antibiotic era, in which common infections and minor injuries which have been treatable for decades can once again kill.

‘Effective antibiotics have been one of the pillars allowing us to live longer, live healthier, and benefit from modern medicine.

‘Unless we take significant actions to improve efforts to prevent infections, and also change how we produce, prescribe and use antibiotics, the world will lose more and more of these global public health goods and the implications will be devastating.

‘We should anticipate to see many more deaths.

‘We are going to see people who have untreatable infections.’

Only last month, Britain’s chief medical officer Dame Sally Davies criticised GPs for needlessly ‘dishing out’ antibiotics to patients.

In the largest study of its kind, the WHO looked at data from 114 countries on seven major types of bacteria. Experts are particularly concerned about bacteria responsible for pneumonia, urinary tract infections, skin infections, diarrhoea and gonorrhoea.

They are also worried that antiviral medicines are becoming increasingly less effective against flu.

Dr Danilo Lo Fo Wong, a senior adviser at the WHO, said: ‘A child falling off their bike and developing a fatal infection would be a freak occurrence in the UK, but that is where we are heading.’

British experts likened the problem to the Aids epidemic of the 1980s. Professor Laura Piddock, who specialises in microbiology at the University of Birmingham, said: ‘The world needs to respond as it did to the Aids crisis.

‘We still need a better understanding of all aspects of resistance as well as new discovery, research and development of new antibiotics.’

The first antibiotic, penicillin, was developed by Sir Alexander Fleming in 1929. But their use has soared since the 1960s, and in 1998 the Government issued guidelines to doctors urging them to curb prescriptions. Nonetheless, surveys suggest they are still prescribed for 80 per cent of coughs, colds and sore throats.

The spread of deadly superbugs that evade even the most powerful antibiotics is happening across the world, United Nations officials have confirmed. Image shows the superbug MRSA which already kills almost 20,000 people a year in Europe

The spread of deadly superbugs that evade even the most powerful antibiotics is happening across the world, United Nations officials have confirmed. Image shows the superbug MRSA which already kills almost 20,000 people a year in Europe

 

THE COUPLE WHO LOST BABY TO INFECTION AFTER SUPERBUG OUTBREAK

Jenna and Andrew Hannon, pictured,  were distraught after losing their son Oliver to a superbug

Jenna and Andrew Hannon, pictured, were distraught after losing their son Oliver to a superbug

The human cost of the rising number of superbugs is becoming all too familiar.

Distraught young couple Jenna and Andrew Hannon lost their second son to an infection at a hospital neo-natal unit in Bristol.

Little Oliver was born early at 24 weeks and although he had seemed well enough to go home with his parents, he soon fell dangerously ill.

He was taken to Southmead Hospital but the infection had taken hold and the youngster passed away.

Tragically the couple had lost another prematurely born son, Travis, to infection in 2010, just five-and-a-half hours after his birth at 26 weeks.

An inquest into Oliver's death later found he had been killed by the pseudomonas bacteria.

He was one of three babies in the hospital to be hit by the killer bacteria, which was later linked to baby deaths around the country.

An investigation took place at the hospital into Oliver's death, but it could not find what caused his infection.

The inquest was told that Oliver was being given two types of antibiotics before he died as a precaution, but neither specifically fought pseudomonas.

As a result of the investigation the hospital also now uses antibiotics which more specifically target the bacteria.

Jennifer Cohn of the international medical charity Médecins Sans Frontières agreed with the WHO's assessment and confirmed the problem had spread to many corners of the world.

'We see horrendous rates of antibiotic resistance wherever we look in our field operations, including children admitted to nutritional centres in Niger, and people in our surgical and trauma units in Syria,' she said.

Earlier this month, Government body NICE said that one in 16 patients are developing infections on NHS wards because of poor hygiene among staff.

NICE said 800 patients a day, the equivalent of 300,000 a year, are infected by a member of staff or by dirty equipment. It is estimated the infections cause 5,000 deaths annually and contribute to another 15,000.

WHAT CAUSES ANTIBIOTIC RESISTANCE?

Antibiotics are substances that kill or interfere with the growth of microorganisms, especially bacteria. But not all microorganisms are susceptible to all antibiotics, according to Public Health England.

Microorganisms which are not killed or inhibited by an antibiotic are called 'antibiotic resistant'.

They continue to grow and multiply in the presence of that antibiotics.

There are several ways in which bacteria can be resistant. Some destroy the antibiotic, for example by producing enzymes against it; some prevent the antibiotic getting into their cells; others get the antibiotic out of their cells before it can harm them.

HOW DOES RESISTANCE DEVELOP?

Some bacteria are naturally resistant; new resistances also arise spontaneously by chance mutations and these resistant strains then multiply.

Some resistances can be passed from one bacterium to another, spreading resistance between species. Loops of DNA (called plasmids) carry the resistance genes from one bacterium to another.

When an antibiotic is given, it kills the sensitive bacteria, but any resistant ones can survive and multiply.

The more antibiotics are used (in animals and agriculture as well as in man) the greater will be the "selective pressure", favouring resistant strains - i.e. survival of the fittest.

Antibiotics don't 'cause' resistance; rather, they create an environment which favours the growth of resistant varians which already exist in nature or arise by chance.

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