The research progress about the role of toyocamycin in the ERS and its antitumor mechanism
Author(s): TIAN Qize, HU Ruicheng, DAI Aiguo, Department of Respiratory, Hunan Mawangdui Hospital Affiliated to University of South China, Institute of Respiratory Disease, Hunan Geriatric Hospital
Pages: 204-208
Year: 2016 Issue: 2
Journal: Journal of Clinical and Pathological Research
Keyword: toyocamycin; endoplasmic reticulum stress; unfold protein response; tumor; antibiotics; apoptosis;
Abstract: Toyocamycin is a purine nucleoside analogue and first to be discovered in streptomyces medium. Toyocamycin can affect the growth of a variety of prokaryotes and eukaryotes; it has significant anti-bacterial, anti-viral, antiparasitic and anti-tumor effects. Because of its strong toxicity, the clinical application of toyocamycin was limited. However, recent studies have found that toyocamycin was closely associated with endoplasmic reticulum stress, and it could kill tumor by interfering the UPR process, while the mechanism is different from previous, suggesting that the role of toyocamycin in antitumor may have a new development. This thesis will review the mechanism of toyocamycin and its developments.
Pages: 204-208
Year: 2016 Issue: 2
Journal: Journal of Clinical and Pathological Research
Keyword: toyocamycin; endoplasmic reticulum stress; unfold protein response; tumor; antibiotics; apoptosis;
Abstract: Toyocamycin is a purine nucleoside analogue and first to be discovered in streptomyces medium. Toyocamycin can affect the growth of a variety of prokaryotes and eukaryotes; it has significant anti-bacterial, anti-viral, antiparasitic and anti-tumor effects. Because of its strong toxicity, the clinical application of toyocamycin was limited. However, recent studies have found that toyocamycin was closely associated with endoplasmic reticulum stress, and it could kill tumor by interfering the UPR process, while the mechanism is different from previous, suggesting that the role of toyocamycin in antitumor may have a new development. This thesis will review the mechanism of toyocamycin and its developments.
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