Author(s): DING Jian, TIAN Li-bin, Department of Gynaecology and Obstetrics, Wuxi Women and Children Healthcare Hospital
Pages: 833-835
Year: 2015 Issue:  11
Journal: Military Medical Journal of South China
Keyword:  GSTA1; Genetic polymorphism; Preeclampsia;
Abstract: Objective To investigate the relationship between Glutathione S-transeferase A1 polymorphism and the risk of preeclampsia in Han pregnant women in Wuxi district. Methods The measurement of polymerase chain reaction-restriction fragment length polymorphism( PCR-RFLP) was performed to genotype all 90 cases with preeclampsia and 90 ethnic and age matched pregnant women as controls in order to analyze the association between GSTA1-69 C / T( rs3957357)and the risk of preeclampsia. Results The frequency of GSTA1 mutant allele GSTA1-69 T was 12. 2 % in case group,while in controls the frequency was 13. 3 %,and there was no significant difference in the two groups( χ~2= 0. 0997,P = 0.752). The frequencies of genotype in the case and control groups had no significant difference neither( χ~2= 0. 7990,P = 0.691). Conclusion The polymorphism of GSTA1( rs3957357) may not be the risk factor of preeclampsia in Han pregnant women in Wuxi district.