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Quality standard of Hongjing capsule
Author(s): KANG Yu-xia, LEI Wan, WANG Ying, GUO Fei-yan, WANG Xiao-juan, College of Pharmacy, Shanxi University of Traditional Chinese Medicine, State Key Laboratory of Military Stomatology, Department of Pharmacy, School of Stomatology, the Fourth Military Medical University
Pages: 335-
339
Year: 2016
Issue:
3
Journal: Liaoning Pharmacy and Clinical Remedies
Keyword: Hongjing capsule; TLC; HPLC; Thalidomide;
Abstract: Objective To establish the quality standard of Hongjing capsule. Methods Borneol and radix notoginseng from Hongjing capsule w ere identified by microscopic identification; Salvia miltiorrhiza,borneol and radix notoginseng w ere identified qualitatively by TLC; HPLC w as adopted to determine the content of thalidomide in the preparation,chromatographic column w as Inertsustain C18( 150 mm × 4. 6 mm,5 μm); acetonitrile-0. 1% phosphoric acid solution( 15∶ 85,v / v) w as as mobile phase,and detection w avelength w as at 237 nm. Results Under the condition of selected TLC,the spot color w as clear and the separation effect w as good. Thalidomide show ed a good linear relationship in the range of 40. 32 ~ 141. 12 μg / m L w ith r = 0. 999 8,and average recovery w as 98. 27% w ith RSD 1.44%( n = 9). Conclusion The method is simple and specific w ith good repeatability and can be used for quality control of Hongjing capsule.
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