Study of Analgesic and Anti-Inflammatory Effect of Chrysanthemum Indicum Supercritical CO2 Extraction
Author(s): ZHENG Jibiao, WU Xiaoli, LIANG Limei, DAI Zhaoyan, SUN Chaoyue, YANG Hongmei, ZHAN Yaxian, LI Yucui, Pharmacy Department, Central Hospital of Zhanjiang, Guangzhou University of Chinese Medicine, Pharmacy Department, People’s Hospital of Guangdong
Pages: 149-152
Year: 2016 Issue: 3
Journal: Pharmacy Today
Keyword: Chrysanthemum indicum; supercritical CO2extraction; analgesic; anti-inflammatory;
Abstract: OBJECTIVE To analyze the activation of analgesic and anti-inflammatory of Chrysanthemum indicum supercritical CO2extraction( SCFE). METHODS The analgesic effect of SCFE was observed by writhing test and hot plate test in mice; antiinflammatory effect was investigated by increased capillary permeability induced by acetic acid and carrageenan-induced paw edema in mice. RESULTS In the writhing test and hot plate test,SCFE significantly reduced the writhing times in 15 min,enhanced the pain threshold; in the increased capillary permeability induced by acetic acid model,it reduced capillary permeability; in the carrageenaninduced paw edema model in mice,SCFE had obvious inhibited effect on the paw edema in mice. CONCLUSION SCFE has significant analgesic and anti-inflammatory effects.
Pages: 149-152
Year: 2016 Issue: 3
Journal: Pharmacy Today
Keyword: Chrysanthemum indicum; supercritical CO2extraction; analgesic; anti-inflammatory;
Abstract: OBJECTIVE To analyze the activation of analgesic and anti-inflammatory of Chrysanthemum indicum supercritical CO2extraction( SCFE). METHODS The analgesic effect of SCFE was observed by writhing test and hot plate test in mice; antiinflammatory effect was investigated by increased capillary permeability induced by acetic acid and carrageenan-induced paw edema in mice. RESULTS In the writhing test and hot plate test,SCFE significantly reduced the writhing times in 15 min,enhanced the pain threshold; in the increased capillary permeability induced by acetic acid model,it reduced capillary permeability; in the carrageenaninduced paw edema model in mice,SCFE had obvious inhibited effect on the paw edema in mice. CONCLUSION SCFE has significant analgesic and anti-inflammatory effects.
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