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The study of ROS1 fusion in advanced primary non-small cell lung cancer and associated metastatic lesions
Author(s): WANG Lin, QI Dongdong, XU Chunwei, LI Li, ZHANG Junping, TAI Yanhong, ZHANG Bo, SHAO Yun, FANG Meiyu, GAO Wenbin, ZHANG Liying, TIAN Yuwang, Department of Pathology, Shanxi Da Hospital, Shanxi Academy of Medical Sciences, Department of Oncology, Zhongshan Hospital, Dalian University, Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Department of Biological Treatment, Shanxi Da Hospital, Shanxi Academy of Medical Sciences, Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, Department of Pathology, the Military General Hospital of Beijing
Pages: 148-
153
Year: 2016
Issue:
2
Journal: Journal of Clinical and Pathological Research
Keyword: non small cell lung cancer; ROS1 fusion gene; primary lesions; metastatic lesions;
Abstract: Objective: To examine the positive rate of ROS1 fusion gene in primary and metastatic non-small cell lung cancer(NSCLC), and to explore their relationships. Methods: From January 2013 to May 2015, a total of 384 cases of primary NSCLC consisting of 246 cases of paired metastatic tumors and 47 cases of normal lung specimens as the control group were collected in the Military General Hospital of Beijing, Affiliated Hospital of Academy of Military Medical Sciences, Zhejiang Cancer Hospital, Zhongshan Hospital of Dalian University, Shanxi Da Hospital, Shanxi Academy of Medical Sciences. The positive rate of ROS1 fusion gene among NSCLC population was figured out, thus the consistency of ROS1 fusion gene in advanced primary NSCLC and associated metastases and the relationship between ROS1 fusion gene and clinical data was analyzed. Results: The positive rate of ROS1 fusion gene on primary tumor was 2.60%(10/384). For those 246 paired cases, the positive rate on primary tumor was 2.85%(7/246), with that of metastases 1.63%(4/246). Among the 246 cases, there were 1 case whose metastases were positive but primary tumors negative and 4 case whose primary tumor was positive but metastases negative. Positive rate of ROS1 fusion gene was higher in the primary lesions than metastases. It was of statistical significance between the two groups(χ2=52.341, P=0.000). The positive rate of primary tumors could be predicted by metastases(κ=0.536, P=0.000). The sensitivity was 42.86%(3/7) and the specificity was 99.58%(238/239). Conclusion: The metastases of non-small cell lung cancer can predict ROS1 fusion gene of the primary lesions. It can be used as alternative means for metastases to detect ROS1 fusion gene which are not readily available.
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