Author(s): SONG Da-yong, LI Zhi-qiang, QUAN Ze, ZHAO Jun, ZHANG Ning, XU Da-yuan, Affiliated Sixth People’s Hospital South Campus, Shanghai Jiaotong University
Pages: 281-283
Year: 2016 Issue:  2
Journal: Acta Anatomica Sinica
Keyword:  Slow virus mediated glioma model; Genetically modified type glioma model; Transplantation of glioma model; Teaching; Student;
Abstract: Objective To compare the application effect in teaching between portability tumor animal models and slow virus mediated glioma model. Methods Fifty students of grade six majoring in eight-year clinical oncology were randomly divided into two teaching groups,25 students per group. Two groups performed different experimental operations:portability tumor animal model group injected rat glioma cell line 9L brain striatum into Wistar rat model,while slow virus mediated glioma model group injected GFAP-Cre mice by Ras expression and Akt activation mediaed by slow virus carrier.The teaching feedback and teaching achievements of two groups after teaching were compared. Results Compared with portability tumor animal model group,the slow virus mediated glioma model group members showed higher feedback of teaching evaluation. The repeatability of the second model was better, which helped students make more sound understanding of tumor at the molecular level. There was a statistically significant difference( P < 0. 05). Conclusion Slow virus mediated glioma model is feasible for application in the teaching,which not only provides a newer model,also makes the students know the tumor at the molecular level,and get thoroughly understanding of the tumor.